Understanding the feasibility and implications of implementing early peanut introduction for prevention of peanut allergy

Abstract

Background A recent randomized trial (the Learning Early About Peanut Allergy [LEAP] study) provided evidence that earlier dietary peanut introduction reduces peanut allergy prevalence in high-risk infants. However, questions remain as to how to identify and target the “at-risk” population to facilitate timely introduction of peanut. Objective We sought to use population-based infant peanut allergy data to understand feasibility and implications of implementing the LEAP trial intervention. Methods Using the HealthNuts study cohort (n = 5276) of 1-year-old infants, we explored the impact of using various criteria to identify infants at high risk of developing peanut allergy, and the implicati..